LymphedemaV1, Main, Exploration, bibRecord, 008F98

T1α/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

Identifieur interne : 008F98 ( Main/Exploration ); précédent : 008F97; suivant : 008F99

T1α/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

Auteurs : Vivien Schacht [États-Unis] ; Maria I. Ramirez [États-Unis] ; Young-Kwon Hong [États-Unis] ; Satoshi Hirakawa [États-Unis] ; Dian Feng [États-Unis] ; Natasha Harvey [États-Unis] ; Mary Williams [États-Unis] ; Ann M. Dvorak [États-Unis] ; Harold F. Dvorak [États-Unis] ; Guillermo Oliver [États-Unis] ; Michael Detmar [États-Unis]

Source :

The EMBO Journal [ 0261-4189 ] ; 2003-07-15.

RBID : ISTEX:80E003BE1F0FF2CE6FC27598831E585D44564B19

Descripteurs français

English descriptors

KwdEn :
- Animals, Animals, Newborn, Cell Adhesion, Cell Movement, Cells, Cultured, Endothelium, Lymphatic (cytology), Endothelium, Lymphatic (embryology), Endothelium, Lymphatic (metabolism), Endothelium, Lymphatic (ultrastructure), Gene Expression Regulation, Developmental, Glycoproteins (metabolism), Glycoproteins (ultrastructure), Homeodomain Proteins (metabolism), Homeodomain Proteins (ultrastructure), Lymphatic System (blood supply), Lymphatic System (cytology), Lymphatic System (embryology), Lymphatic System (pathology), Lymphedema (etiology), Lymphedema (pathology), Membrane Glycoproteins (deficiency), Membrane Glycoproteins (metabolism), Membrane Glycoproteins (ultrastructure), Membrane Proteins (deficiency), Membrane Proteins (metabolism), Membrane Proteins (physiology), Mice, Mice, Knockout, Neovascularization, Physiologic (genetics), RNA, Small Interfering (metabolism), Tumor Suppressor Proteins.
MESH :
- chemical , deficiency : Membrane Glycoproteins, Membrane Proteins.
- chemical , metabolism : Glycoproteins, Homeodomain Proteins, Membrane Glycoproteins, Membrane Proteins, RNA, Small Interfering.
- blood supply : Lymphatic System.
- cytology : Endothelium, Lymphatic, Lymphatic System.
- embryology : Endothelium, Lymphatic, Lymphatic System.
- etiology : Lymphedema.
- genetics : Neovascularization, Physiologic.
- metabolism : Endothelium, Lymphatic.
- pathology : Lymphatic System, Lymphedema.
- chemical , physiology : Membrane Proteins.
- ultrastructure : Endothelium, Lymphatic, Glycoproteins, Homeodomain Proteins, Membrane Glycoproteins.
- Animals, Animals, Newborn, Cell Adhesion, Cell Movement, Cells, Cultured, Gene Expression Regulation, Developmental, Mice, Mice, Knockout, Tumor Suppressor Proteins.

Abstract

Within the vascular system, the mucin‐type transmembrane glycoprotein T1α/podoplanin is predominantly expressed by lymphatic endothelium, and recent studies have shown that it is regulated by the lymphatic‐specific homeobox gene Prox1. In this study, we examined the role of T1α/podoplanin in vascular development and the effects of gene disruption in mice. T1α/podoplanin is first expressed at around E11.0 in Prox1‐positive lymphatic progenitor cells, with predominant localization in the luminal plasma membrane of lymphatic endothelial cells during later development. T1α/podoplanin−/− mice die at birth due to respiratory failure and have defects in lymphatic, but not blood vessel pattern formation. These defects are associated with diminished lymphatic transport, congenital lymphedema and dilation of lymphatic vessels. T1α/podoplanin is also expressed in the basal epidermis of newborn wild‐type mice, but gene disruption did not alter epidermal differentiation. Studies in cultured endothelial cells indicate that T1α/podoplanin promotes cell adhesion, migration and tube formation, whereas small interfering RNA‐mediated inhibition of T1α/podoplanin expression decreased lymphatic endothelial cell adhesion. These data identify T1α/podoplanin as a novel critical player that regulates different key aspects of lymphatic vasculature formation.

Url:

DOI: 10.1093/emboj/cdg342

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Animals, Newborn</term>
<term>Cell Adhesion</term>
<term>Cell Movement</term>
<term>Cells, Cultured</term>
<term>Endothelium, Lymphatic (cytology)</term>
<term>Endothelium, Lymphatic (embryology)</term>
<term>Endothelium, Lymphatic (metabolism)</term>
<term>Endothelium, Lymphatic (ultrastructure)</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Glycoproteins (metabolism)</term>
<term>Glycoproteins (ultrastructure)</term>
<term>Homeodomain Proteins (metabolism)</term>
<term>Homeodomain Proteins (ultrastructure)</term>
<term>Lymphatic System (blood supply)</term>
<term>Lymphatic System (cytology)</term>
<term>Lymphatic System (embryology)</term>
<term>Lymphatic System (pathology)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (pathology)</term>
<term>Membrane Glycoproteins (deficiency)</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>Membrane Glycoproteins (ultrastructure)</term>
<term>Membrane Proteins (deficiency)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Membrane Proteins (physiology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Neovascularization, Physiologic (genetics)</term>
<term>RNA, Small Interfering (metabolism)</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adhérence cellulaire</term>
<term>Animaux</term>
<term>Animaux nouveau-nés</term>
<term>Cellules cultivées</term>
<term>Endothélium lymphatique (cytologie)</term>
<term>Endothélium lymphatique (embryologie)</term>
<term>Endothélium lymphatique (métabolisme)</term>
<term>Endothélium lymphatique (ultrastructure)</term>
<term>Glycoprotéines (métabolisme)</term>
<term>Glycoprotéines (ultrastructure)</term>
<term>Glycoprotéines membranaires (déficit)</term>
<term>Glycoprotéines membranaires (métabolisme)</term>
<term>Glycoprotéines membranaires (ultrastructure)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (étiologie)</term>
<term>Mouvement cellulaire</term>
<term>Néovascularisation physiologique (génétique)</term>
<term>Petit ARN interférent (métabolisme)</term>
<term>Protéines membranaires (déficit)</term>
<term>Protéines membranaires (métabolisme)</term>
<term>Protéines membranaires (physiologie)</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Protéines à homéodomaine (métabolisme)</term>
<term>Protéines à homéodomaine (ultrastructure)</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Système lymphatique ()</term>
<term>Système lymphatique (anatomopathologie)</term>
<term>Système lymphatique (cytologie)</term>
<term>Système lymphatique (embryologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Membrane Proteins</term>
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<term>Homeodomain Proteins</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Proteins</term>
<term>RNA, Small Interfering</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term>
<term>Système lymphatique</term>
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</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Endothélium lymphatique</term>
<term>Système lymphatique</term>
</keywords>
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<term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines membranaires</term>
</keywords>
<keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Endothélium lymphatique</term>
<term>Système lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Endothelium, Lymphatic</term>
<term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Neovascularization, Physiologic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Néovascularisation physiologique</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelium, Lymphatic</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Endothélium lymphatique</term>
<term>Glycoprotéines</term>
<term>Glycoprotéines membranaires</term>
<term>Petit ARN interférent</term>
<term>Protéines membranaires</term>
<term>Protéines à homéodomaine</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic System</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines membranaires</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Membrane Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Endothelium, Lymphatic</term>
<term>Glycoproteins</term>
<term>Homeodomain Proteins</term>
<term>Membrane Glycoproteins</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Endothélium lymphatique</term>
<term>Glycoprotéines</term>
<term>Glycoprotéines membranaires</term>
<term>Lymphoedème</term>
<term>Protéines à homéodomaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Animals, Newborn</term>
<term>Cell Adhesion</term>
<term>Cell Movement</term>
<term>Cells, Cultured</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adhérence cellulaire</term>
<term>Animaux</term>
<term>Animaux nouveau-nés</term>
<term>Cellules cultivées</term>
<term>Mouvement cellulaire</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Système lymphatique</term>
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<front><div type="abstract">Within the vascular system, the mucin‐type transmembrane glycoprotein T1α/podoplanin is predominantly expressed by lymphatic endothelium, and recent studies have shown that it is regulated by the lymphatic‐specific homeobox gene Prox1. In this study, we examined the role of T1α/podoplanin in vascular development and the effects of gene disruption in mice. T1α/podoplanin is first expressed at around E11.0 in Prox1‐positive lymphatic progenitor cells, with predominant localization in the luminal plasma membrane of lymphatic endothelial cells during later development. T1α/podoplanin−/− mice die at birth due to respiratory failure and have defects in lymphatic, but not blood vessel pattern formation. These defects are associated with diminished lymphatic transport, congenital lymphedema and dilation of lymphatic vessels. T1α/podoplanin is also expressed in the basal epidermis of newborn wild‐type mice, but gene disruption did not alter epidermal differentiation. Studies in cultured endothelial cells indicate that T1α/podoplanin promotes cell adhesion, migration and tube formation, whereas small interfering RNA‐mediated inhibition of T1α/podoplanin expression decreased lymphatic endothelial cell adhesion. These data identify T1α/podoplanin as a novel critical player that regulates different key aspects of lymphatic vasculature formation.</div>
</front>
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<name sortKey="Hirakawa, Satoshi" sort="Hirakawa, Satoshi" uniqKey="Hirakawa S" first="Satoshi" last="Hirakawa">Satoshi Hirakawa</name>
<name sortKey="Hong, Young Won" sort="Hong, Young Won" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
<name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
<name sortKey="Ramirez, Maria I" sort="Ramirez, Maria I" uniqKey="Ramirez M" first="Maria I." last="Ramirez">Maria I. Ramirez</name>
<name sortKey="Williams, Mary" sort="Williams, Mary" uniqKey="Williams M" first="Mary" last="Williams">Mary Williams</name>
<name sortKey="Williams, Mary" sort="Williams, Mary" uniqKey="Williams M" first="Mary" last="Williams">Mary Williams</name>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:80E003BE1F0FF2CE6FC27598831E585D44564B19
   |texte=   T1α/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
}}

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Serveur d'exploration sur le lymphœdème

T1α/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

T1α/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

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	Serveur d'exploration sur le lymphœdème
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